19

The role of endogenous macrophages in the development of MSC-delivered therapy in osteosarcoma xenograft models

Osteosarcoma is the most common primary bone cancer largely affecting children and adolescents. It is the second highest cause of cancer-related death in childhood. Usually 25% of patients develop metastasis in lung despite surgical removal of tumor and chemotherapy. MSCs exhibit an intrinsic homing property to inflammation and tumor sites. Several studies confirmed the migration of MSCs toward different tumors. Our objective was to develop a mouse model of osteosarcoma, investigate hMSC migration to tumor area, how to increase the migration ability, how to overcome restrictions hereby improve the immunotherapeutic strategy in the treatment of osteosarcoma and other tumors.